An in Vitro Approach to Evaluate and Develop Potential 117mSn-based Bone-seeking Radiopharmaceuticals

Download or read book An in Vitro Approach to Evaluate and Develop Potential 117mSn-based Bone-seeking Radiopharmaceuticals written by David Randall Jansen and published by IOS Press. This book was released on 2010 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Testing on animals has become standard practice for evaluating the potential efficacy of therapeutic or diagnostic agents. Not only are the overhead costs of such testing extremely high, but subjecting substantial numbers of animals to intensive testing and re-testing raises serious ethical questions and is widely unpopular with the public. This study explores the advantages of combining various analytical methods with mathematical and computer modeling to construct a multifaceted tool for the pre-vivo screening of prospective radiopharmaceuticals. The benefits of such a method lie in cost minimization and the avoidance of the ethical dimension. The 117mSn radionuclide was identified as an ideal pharmacological component for the treatment of bone pain, and two tin-bisphosponate complexes - Sn(II)-APDDMP and Sn(IV)-PEI-MP were chosen for evaluation. This book describes how these complexes were studied using various techniques.