This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors f

The elucidation of the cellular and molecular bases underlying the inte grated function of the central nervous system, both in disease and in health, must ultim

PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and