Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System
Author :
Publisher : National Academies Press
Total Pages : 74
Release :
ISBN-10 : 9780309212212
ISBN-13 : 0309212219
Rating : 4/5 (219 Downloads)

Book Synopsis Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by : Institute of Medicine

Download or read book Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine and published by National Academies Press. This book was released on 2011-08-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.


Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System Related Books

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System
Language: en
Pages: 74
Authors: Institute of Medicine
Categories: Medical
Type: BOOK - Published: 2011-08-05 - Publisher: National Academies Press

DOWNLOAD EBOOK

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, current
The Glutamate/GABA-Glutamine Cycle
Language: en
Pages: 420
Authors: Arne Schousboe
Categories: Medical
Type: BOOK - Published: 2016-11-25 - Publisher: Springer

DOWNLOAD EBOOK

Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that
GABA And Glutamate
Language: en
Pages: 139
Authors: Janko Samardzic
Categories: Medical
Type: BOOK - Published: 2018-03-21 - Publisher: BoD – Books on Demand

DOWNLOAD EBOOK

This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotra
GABA in the Nervous System
Language: en
Pages: 538
Authors: David L. Martin (M.D.)
Categories: Medical
Type: BOOK - Published: 2000 - Publisher:

DOWNLOAD EBOOK

GABA in the Nervous System summarizes recent advances in understanding the role of GABA as a neurotransmitter. First discovered as an inhibitory signal in 1950,
Magnesium in the Central Nervous System
Language: en
Pages: 354
Authors: Robert Vink
Categories: Medical
Type: BOOK - Published: 2011 - Publisher: University of Adelaide Press

DOWNLOAD EBOOK

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and func