Harnessing Oncolytic Virus-mediated Antitumor Immunity
Author | : Philippe Fournier |
Publisher | : Frontiers Media SA |
Total Pages | : 111 |
Release | : 2015-03-02 |
ISBN-10 | : 9782889194506 |
ISBN-13 | : 2889194507 |
Rating | : 4/5 (507 Downloads) |
Download or read book Harnessing Oncolytic Virus-mediated Antitumor Immunity written by Philippe Fournier and published by Frontiers Media SA. This book was released on 2015-03-02 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.