Modulation of Cortical-limbic Pathways in Major Depression [microform] : Treatment-specific Effect of Cognitive Behavior Therapy

Download or read book Modulation of Cortical-limbic Pathways in Major Depression [microform] : Treatment-specific Effect of Cognitive Behavior Therapy written by Kimberly Goldapple and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2004 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Objective. Neuroimaging studies of depression demonstrate response-specific changes following various antidepressant treatments. Changes associated with cognitive behavior therapy (CBT) have not been reported. Results. CBT was associated with metabolic changes: increases in hippocampus and dorsal cingulate, decreases in dorsal, ventral and medial frontal cortex. This pattern is distinct from that seen with paroxetine response where prefrontal increases and hippocampal and subgenual cingulate decreases were seen. Method. Brain changes associated with CBT were examined using positron emission tomography. Seventeen depressed patients were scanned before and after 15--20 therapy sessions. A post hoc comparison to thirteen paroxetine treated responders was performed to interpret the specificity of CBT effects. Conclusions. CBT may affect recovery by modulating the functioning of specific sites in limbic and cortical regions. Unique directional changes in frontal cortex, cingulate and hippocampus with CBT relative to paroxetine may reflect modality-specific effects with implications for understanding mechanisms underlying different treatments.