Resistance to Molecular Therapies for Hepatocellular Carcinoma
Author | : Augusto Villanueva |
Publisher | : Springer |
Total Pages | : 153 |
Release | : 2017-07-14 |
ISBN-10 | : 9783319561974 |
ISBN-13 | : 3319561979 |
Rating | : 4/5 (979 Downloads) |
Download or read book Resistance to Molecular Therapies for Hepatocellular Carcinoma written by Augusto Villanueva and published by Springer. This book was released on 2017-07-14 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.