Neuron-To-Neuron Wild-Type Tau Protein Transfer Through a Trans-Synaptic Mechanism

Download or read book Neuron-To-Neuron Wild-Type Tau Protein Transfer Through a Trans-Synaptic Mechanism written by Applied Research Press and published by CreateSpace. This book was released on 2015-08-09 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the hierarchical pathways of this neurodegeneration have been well established in Alzheimer's disease (AD) and other sporadic tauopathies such as argyrophilic grain disorder and progressive supranuclear palsy but the molecular and cellular mechanisms supporting this progression are yet not known. These pathways appear to be associated with the intercellular transmission of pathology, as recently suggested in Tau transgenic mice. However, these conclusions remain ill-defined due to a lack of toxicity data and difficulties associated with the use of mutant Tau. Taken together, these results support a novel mechanism for Tau protein transfer compared to previous reports based on transgenic models with mutant cDNA. It also demonstrates that mutant Tau proteins are not suitable for the development of experimental models helpful to validate therapeutic intervention interfering with Tau spreading.