Osteopontin
| Author | : David T. Denhardt |
| Publisher | : |
| Total Pages | : 420 |
| Release | : 1995 |
| ISBN-10 | : STANFORD:36105012377672 |
| ISBN-13 | : |
| Rating | : 4/5 ( Downloads) |
Book Synopsis Osteopontin by : David T. Denhardt
Download or read book Osteopontin written by David T. Denhardt and published by . This book was released on 1995 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteopontin is a GRGDS-containing phosphoprotein secreted by most epithelial cells, many cancer cells, and stimulated or activated cells of various types including smooth muscle cells, fibroblasts and macrophages. It is a ligand for the avb3 integrin, promoting cell adhesion and triggering a signal transduction pathway that can influence gene expression. Binding multiple Ca++ ions, osteopontin is involved in the formation and remodelling of mineralised tissues and Ca++ homeostasis; it has also been implicated in host defence mechanisms.
