Antisense Technology in the Central Nervous System

Download or read book Antisense Technology in the Central Nervous System written by Ronald A. Leslie and published by Oxford University Press, USA. This book was released on 1999 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antisense technology has been used for several years to "knock down" the expression of specific genes in living tissues to study the functions of their protein products. Specifically designed antisense oligonucleotides (ODNs) are short lengths of man-made genetic material designed to interferewith the production of the protein encoded by the gene. This can shed light on the function of the protein; alternatively, if a disease process results from an excess of a certain protein, the method can in theory correct the problem. Faster than transgenic techniques, but more problematic inpractice, antisense has been seen as something of a "black art". There are many technical problems to understand and overcome.This is the first book to provide a critical review of the uses of this technology in the central nervous system. It includes: Background to the technology problems of design and synthesis of antisense molecules administration in the brain protection of ODNs from metabolic destruction potent forCNS research and therapy. Antisense Technology in the Central Nervous System describes the promises and the pitfalls of this approach, and compares it to other approaches. The practical experience of leading researchers is combined with a thorough description of the theoretical foundation of thetechnique, making the book ideal for researchers and clinicians alike.