Assessment of Immune status by the Leukocyte Adherence Inhibition Test

Download or read book Assessment of Immune status by the Leukocyte Adherence Inhibition Test written by D Thomson and published by Elsevier. This book was released on 2012-12-02 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assessment of Immune Status by the Leukocyte Adherence Inhibition Test reviews many aspects of the immune response and cellular requirements in leukocyte adherence inhibition (LAI). It compares the LAI methodology with alternative approaches, discusses the method that has been adopted to determine whether the LAI phenomenon measures a specific immune response, and explores how these phenomena fit in with and relate to the traditional immune response. Organized into three parts encompassing 15 chapters, this volume begins with an overview of the hemocytometer assay, the immunological basis and applications of hemocytometer LAI, the immune response as assayed by the test tube method, and the microplate assay. It then discusses cellular populations in LAI; measurements of humoral antitumor immunity; clinical application of LAI in breast cancer, prostate cancer, and rheumatic diseases; the biology of LAI and its response to human cancer; and cellular and pharmacologic aspects of LAI. It also compares microplate LAI with other in vitro assays of cell-mediated immunity, as well as tumor immunity in animal models and human cancer. Both beginning and experienced investigators involved in all aspects of immunologic research will find this book extremely useful.