Development of Neutral Redox Carbon-carbon Bond Forming Reactions Via Transition Metal-catalyzed Transfer Hydrogenation
Author | : Khoa Dang Nguyen (Ph. D.) |
Publisher | : |
Total Pages | : 1316 |
Release | : 2017 |
ISBN-10 | : OCLC:1020853164 |
ISBN-13 | : |
Rating | : 4/5 ( Downloads) |
Download or read book Development of Neutral Redox Carbon-carbon Bond Forming Reactions Via Transition Metal-catalyzed Transfer Hydrogenation written by Khoa Dang Nguyen (Ph. D.) and published by . This book was released on 2017 with total page 1316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since C-C bonds form the backbone of every organic molecule and reside at the heart of chemical science, the development of new efficient methods for promoting C-C bond formation is of great significance. Inspired and expanded from traditional Grignard reactions, the work presented in this dissertation focuses on metal catalyzed neutral redox-triggered carbonyl addition via transfer hydrogenation. Advancing the native reducing capability of alcohols, employment of catalytic transition metals enables the formation of nucleophile-electrophile pairs in situ, en route to the products of formal alcohol C-H functionalization. These redox-triggered reactions circumvent the stoichiometric metallated byproduct waste and streamline the construction of complex molecules from simple and/or readily available feedstocks. The research reported herein discloses new developed methodologies of ruthenium and iridium catalyzed coupling reactions of primary and secondary alcohols with various pi-unsaturates. These studies contribute to the growing body of redox-triggered alcohol C-C couplings - new carbonyl addition chemistry that extends beyond the use of premetalated reagents.