Epigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome

Download or read book Epigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome written by Tania L Roth and published by Frontiers Media SA. This book was released on 2015-04-14 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry.