Implementation of Chemical Protein-nucleic Acid Cross-linking Into Mass Spectrometric Workflows and Mass Spectrometric Database Searches
Author | : Fanni Laura Bazsó |
Publisher | : |
Total Pages | : |
Release | : 2021 |
ISBN-10 | : OCLC:1285985050 |
ISBN-13 | : |
Rating | : 4/5 ( Downloads) |
Download or read book Implementation of Chemical Protein-nucleic Acid Cross-linking Into Mass Spectrometric Workflows and Mass Spectrometric Database Searches written by Fanni Laura Bazsó and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein nucleic acid interactions play a pivotal role in cells, from transcription to translation. Functions of proteins in protein nucleic acid interactions are diverse: histones are responsible for the packaging of the genomic DNA; ribosomal proteins are part of the ribosome, which is responsible for protein synthesis. Crosslinking mass spectrometry proved to be a useful tool to identify protein-nucleic acid interactions and their dynamics in the cell. A vast amount of effort has been spent to elucidate protein-nucleic acid interactions with UV crosslinking mass spectrometry, whereas chem...