Multi-Scale Photoacoustic Tomography and Its Applications to Cancer Research

Download or read book Multi-Scale Photoacoustic Tomography and Its Applications to Cancer Research written by Lei Xi and published by . This book was released on 2012 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second part of the dissertation focuses on developing acoustic-resolution photoacoustic microscopy (ARPAM) that breaks the limitation of imaging depth associated with ORPAM. We demonstrate the applications of ARPAM to anti-angiogenesis medicine study of breast cancer and to molecular imaging of breast and ovarian cancers with targeted nanoprobes. The third part of my dissertation is concerned with intraoperative photoacoustic tomography (iPAT) miniature probe for image-guided surgery of breast cancer. The probe is evaluated with phantom and in vivo experiments in an animal model. The fourth part of my dissertation focuses on integrating circular array-based photoacoustic tomography system with diffuse optical tomography system. Several sets of phantom experiments with embedded tumor mimicking targets and ex vivo tumor are used to evaluate the performance of this hybrid system. In the last part of the dissertation, conclusions are made and future directions are discussed.