Nitric Oxide Synthase Genetic Regulation and Contribution to Aminoglycoside Sensitivity in Staphylococcus Aureus
Author | : Jessica Nicole Brandwein |
Publisher | : |
Total Pages | : 0 |
Release | : 2022 |
ISBN-10 | : OCLC:1375392764 |
ISBN-13 | : |
Rating | : 4/5 ( Downloads) |
Download or read book Nitric Oxide Synthase Genetic Regulation and Contribution to Aminoglycoside Sensitivity in Staphylococcus Aureus written by Jessica Nicole Brandwein and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: strain-dependent, as nos expression remained unchanged in an agr mutant in a USA300 strain, which has higher Agr activity compared to UAMS-1 (USA200 strain). Furthermore, nos expression was higher in USA300 relative to UAMS-1 during late-exponential low-oxygen growth, when nos expression is maximal. Global regulators Rex and MgrA were also implicated as negative regulators of nos expression in UAMS-1. Finally, mapping of the nos transcriptional start site revealed that the nos transcript may be subject to processing or may be a leaderless mRNA. Collectively, these results provide new insight into the transcriptomic response of S. aureus to gentamicin treatment as well as factors that control nos expression. Observed strain-dependent differences reinforce the importance of studying bacterial NOS regulation and function at both the strain and species level.