Regulation of HIV-1 Postintegration Latency by NF-kappa-B.

Download or read book Regulation of HIV-1 Postintegration Latency by NF-kappa-B. written by Samuel A. F. Williams and published by . This book was released on 2005 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: In our initial study, we identified the phorbol ester prostratin as an inducer of latent HIV-1 gene expression in the J-Lat model of latency. We demonstrated a central role for the NF-kappaB family of transcription factors as mediators of prostratin antagonism of HIV, and for the first demonstrated recruitment of NF-kappaB RelA to the HIV-1 LTR in vivo. These studies prompted us to investigate in more detail the processes regulated by NF-kappaB that modulate expression of latent HIV-1.