Single-Domain Antibodies—Biology, Engineering and Emerging Applications, volume II

Download or read book Single-Domain Antibodies—Biology, Engineering and Emerging Applications, volume II written by Kevin A. Henry and published by Frontiers Media SA. This book was released on 2024-12-30 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is the second volume of Single-Domain Antibodies: Biology, Engineering and Emerging Applications. Please see volume I here. Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as parts of the heavy-chain-only antibodies of camelid ruminants and cartilaginous fishes. For applications requiring antibody fragments, sdAbs have significant advantages over fragments derived from conventional antibodies such as Fabs or scFvs. The scope of this Research Topic covers current understanding and new developments in (i) the biology, immunology, and genetics of sdAbs in camelids and sharks, (ii) approaches for the isolation and characterization of sdAbs, (iii) strategies for optimizing sdAb solubility, stability, and antigen binding properties and for reducing their immunogenicity, and (iv) specialized applications of sdAbs, including as therapeutics, diagnostics, imaging agents, cellular and molecular probes, and as tools for developmental and structural biology.