Studies Directed Toward the Synthesis of the B-type Amphidinolide Natural Products Using Nickel-catalyzed Reductive Couplings of Enynes and Carbonyl Compounds
Author | : Andrew Michael Lauer |
Publisher | : |
Total Pages | : 241 |
Release | : 2010 |
ISBN-10 | : OCLC:655319475 |
ISBN-13 | : |
Rating | : 4/5 ( Downloads) |
Download or read book Studies Directed Toward the Synthesis of the B-type Amphidinolide Natural Products Using Nickel-catalyzed Reductive Couplings of Enynes and Carbonyl Compounds written by Andrew Michael Lauer and published by . This book was released on 2010 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress coupling of substrates, toward the total synthesis of amphidinolide B1 is described. The reductive 1,3-eynes and ketones was explored. It was found to work well with simple but failed to yield intermediates toward amphidinolide B1 [images] ... The coupling of 1,3-enyne and aldehyde fragments toward the synthesis of amphidinolides G3 and H4 is also described. The entire carbon skeleton of these natural products has been prepared from this coupling and a subsequent installation of a methyl group using an indium based reagent ... [images].