Synthetic Studies Toward the Total Synthesis of Superstolides A and B

Download or read book Synthetic Studies Toward the Total Synthesis of Superstolides A and B written by Zhengmao Hua and published by . This book was released on 2006 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: An alternative approach was developed for the synthesis of bicyclo [2.2.2) octane. The key reaction of this approach is an asymmetric Diels-Alder reaction employing 1,3-diene that derived from R-4-t-butyldimethyl-silyloxy-2-cyclohexen-one. We have successfully achieved full control of the facile and stereoselectivity of this novel Diels-Alder reaction. The product of this reaction, a bicyclo[2.2.2]octane, is a very useful building block, and this methodology is expected to be widely used in organic synthesis.