Transplantation and Cellular Therapy in Lymphomas and Plasma Cell Disorders

Download or read book Transplantation and Cellular Therapy in Lymphomas and Plasma Cell Disorders written by Saad Zafar Usmani and published by Frontiers Media SA. This book was released on 2024-12-31 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematopoietic Cell Transplantation (HCT) has significantly improved the survival of patients with lymphomas and plasma cell disorders (PCD). The safety and effectiveness of this procedure have improved over recent years. Named by ASCO in 2018 as the Advance of the Year, CAR T cell therapies are increasingly utilized in the management of lymphomas and PCD since the initial FDA approval in 2017 and are being given earlier in the course of disease, transforming the care of these diseases. Ongoing basic work promises to improve CAR T effectiveness and accessibility. This Research Topic describes the present role of CAR Ts, their impact on the role of HCT and the future of these 2 therapies in lymphomas and PCD. The goal of this Research Topic is to provide basic background information on HCT and CAR T therapy, discuss their present roles in the management of lymphomas and PCD, focusing on recent progress, address practical technical issues as well as obstacles to broader use, and predict the future of these two modalities, based on current research. Numerous studies have demonstrated substantial deficits in the understanding by many practitioners of the appropriate role and timing of HCT. These shortcomings have led to underutilization and inappropriate timing of referral for transplantation. Given its very recent approval and growth, the need for understanding the basic work and practical aspects of CAR T therapy, including barriers to care, is even more pronounced. This issue will educate practitioners and others with transplantation and/or cellular therapy interest on basic background, best practice, and broad understanding of the power and limitations of these two therapies in lymphoma and PCD.